Stanley Druckenmiller likes to make huge bets.
The 72-year-old billionaire as soon as mentioned that when you see one thing actually thrilling, “Bet the ranch on it.”
With the tech-heavy Nasdaq Composite down about 2% 12 months to this point, maybe his latest strikes can supply buyers some hints.
Druckenmiller was previously George Soros’s right-hand man. He helped make the well-known guess towards the British pound in 1992, a commerce that “broke the Bank of England.”
He’s the previous chairman and president of Duquesne Capital Administration, which he based in 1981 and managed till it closed in 2010. Over its almost three many years, the agency delivered a median annual return of 30%.
After Druckenmiller closed Duquesne Capital to exterior buyers, he actively managed his wealth and investments beneath a household workplace construction, now referred to as Duquesne Household Workplace.
Duquesne Household Workplace returned 37% over the previous 12 months and gained 123.25% over the previous 5 years, in accordance with knowledge from Stockcircle.
Duquesne Household Workplace returned 37% over the previous 12 months.
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Druckenmiller buys $152 million in Amazon and Google, exits Meta
Some megacap know-how names have been amongst Druckenmiller’s most notable buys within the fourth quarter of 2025, in accordance with Whalewisdom’s knowledge based mostly on 13F filings.
Amazon (AMZN) remained one of many fund’s largest positions, with Druckenmiller including 300,870 shares value about $63 million, growing the stake by 68.8%. Amazon is the fund’s seventh-largest holding.
Notably, Amazon was additionally one in all George Soros’s fund’s largest buys within the fourth quarter, with Soros Fund Administration including 133,385 shares.
Associated: Billionaire George Soros buys $137M in AI chips, trims Alphabet
Druckenmiller additionally sharply raised his Alphabet (GOOGL) place by 276.7% from the earlier quarter, including 282,800 shares value roughly $89 million.
Druckenmiller’s strikes come as each firms proceed to ramp up spending on synthetic intelligence infrastructure and cloud. Shares of the Google dad or mum surged roughly 30% in the course of the fourth quarter, whereas Amazon gained 5%.
In distinction, Druckenmiller absolutely exited Meta, promoting all 76,100 shares after the inventory tumbled 10% within the earlier quarter.
Inside semiconductors, Druckenmiller lowered his Taiwan Semiconductor (TSM) stake by 29%, bringing it to his eighth-largest holding, down from the fourth-largest place in Q3 2025.
TSMC is the world’s largest chip foundry and a essential producer for Nvidia (NVDA) and different AI chip makers.
On Jan. 15, the corporate posted robust fourth-quarter outcomes, as earnings per ADR rose 35% 12 months over 12 months to $3.14. Income for the quarter reached $33.73 billion, up 25.5% from a 12 months in the past. Gross margin, a key profitability measure, was 62.3%, up from 59.5% a 12 months in the past.
Druckenmiller initiated a brand new place in ON Semiconductor (ON), a smaller guess value $29 million.
Druckenmiller slashed well being care, betting on airways and Brazil
Well being care stays Druckenmiller’s largest publicity, although a number of positions have been lowered.
Natera (NTRA) stays Druckenmiller’s high holding at 12.75% of the portfolio, regardless of a roughly 22% trim. Teva Pharmaceutical (TEVA) was reduce sharply by 64.6%. Insmed (INSM) was additionally dumped by 38.9%.
Regardless of the reductions, the three well being care names stay amongst Druckenmiller’s high 5 holdings. The well being care sector is commonly thought of defensive, because the demand for services is comparatively steady.
High 10 holdings of Duquesne Household Workplace as of Dec. 31, 2025:
- Natera (NTRA): 12.80%
- Monetary Choose Sector SPDR Fund (XLF): 6.70%
- Insmed (INSM): 5.74%
- Invesco S&P 500 Equal Weight ETF (RSP): 5.00%
- Teva Pharmaceutical (TEVA): 4.08%
- Woodward (WWD): 3.97%
- Amazon (AMZN): 3.79%
- Taiwan Semiconductor (TSM): 3.67%
- Coupang (CPNG): 3.55%
- iShares MSCI Brazil ETF Name Choices (EWZ name): 2.99%
Druckenmiller moved again into airways, reopening positions in United Airways (UAL), Delta Air Strains (DAL), and American Airways (AAL), after having exited United and Delta within the third quarter of 2025 and American earlier within the second quarter.
On the similar time, Druckenmiller made a large guess on Brazil.
He established new positions within the iShares MSCI Brazil ETF (EWZ) and name choices tied to the identical fund. In whole, the trades signify greater than 5% of the portfolio, one of many largest new bets within the submitting.
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